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R 59022
CAS No. 93076-89-2
R 59022 ( R 59-022 | R59022 )
产品货号. M16660 CAS No. 93076-89-2
一种二酰甘油激酶 (DGK) 的小分子抑制剂，IC50 为 2.8 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2082 | 有现货 |
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| 50MG | ￥8060 | 有现货 |
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| 100MG | ￥12798 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称R 59022
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种二酰甘油激酶 (DGK) 的小分子抑制剂，IC50 为 2.8 uM。
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产品描述A small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 2.8 uM, inhibits the phosphorylation of OAG to OAPA with IC50 of 3.8 uM in intact platelets; concomitantly stimulates PKC activity, selectively suppresses U46619-induced enhancement of mouse portal vein contraction under high glucose conditions; also induces caspase-mediated apoptosis in glioblastoma cells and in other cancers, but lacks toxicity in noncancerous cells.
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体外实验Western Blot Analysis Cell Line:HeLa cells Concentration:40 uM Incubation Time:30 min Result:Increased the phosphorylation of PKC downstream targets by about 2.5-fold.
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体内实验Animal Model:SCID mice implanted with U87 GBM cells Dosage:10 mg/kg Administration:Intraperitoneal injection (i.p.) Result:Increased median survival and decreased tumor volume.
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同义词R 59-022 | R59022
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通路Others
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靶点DGK
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受体DGK
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研究领域——
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适应症——
化学信息
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CAS Number93076-89-2
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分子量459.58
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分子式C27H26FN3OS
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 62.5 mg/mL (135.99 mM)
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SMILESO=C1C(CCN2CC/C(CC2)=C(C3=CC=C(F)C=C3)\C4=CC=CC=C4)=C(C)N=C5N1C=CS5
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化学全称6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Dominguez CL, et al. Cancer Discov. 2013 Jul;3(7):782-97.
2. de Chaffoy de Courcelles DC, et al. J Biol Chem. 1985 Dec 15;260(29):15762-70.
3. Nunn DL, et al. Biochem J. 1987 May 1;243(3):809-13.
4. Nobe K, et al. Br J Pharmacol. 2004 Sep;143(1):166-78.
